CALCRL - Calcitonin gene-related peptide type 1 receptor - human protein (Function)
 
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CALCRL »  Calcitonin gene-related peptide type 1 receptor  (CGRP type 1 receptor)
 
Protein also known as:  Calcitonin receptor-like receptor.
Gene name:  CALCRL
Entry whose protein(s) existence is based on evidence at protein level
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1 60 1
GENE REF ISO

Function

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Overview 
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.12  
GO molecular function 
Adrenomedullin receptor activitydefinition[GO:0001605]  
1
  • IDAUniProtKB
Calcitonin gene-related polypeptide receptor activitydefinition[GO:0001635] silver  
  • IEAOrtholog Compara
Calcitonin receptor activitydefinition[GO:0004948] silver  
  • IEAOrtholog Compara
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein transporter activitydefinition[GO:0008565]  
1
  • IDAUniProtKB
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525]  
1
  • IDAUniProtKB
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • IDAUniProtKB
Cellular response to sucrose stimulusdefinition[GO:0071329]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDAUniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Protein transportdefinition[GO:0015031]  
1
  • IDAUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Regulation of muscle contractiondefinition[GO:0006937] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+10203  
Vascular smooth muscle contraction  hsa04270+10203  
According to Reactome, this protein belongs to the following pathways:
Calcitonin-like ligand receptors  REACT_18290  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CALCRL
GenomeRNAi: 10203
PRO: PR:Q16602