BAK1 - Bcl-2 homologous antagonist/killer - human protein (Function)
 
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BAK1 »  Bcl-2 homologous antagonist/killer
 
Protein also known as:  Apoptosis regulator BAK.
Gene name:  BAK1
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
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1 194 2
GENE REF ISO

Function

 show evidences
Overview 
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the bcl-2 (bcl-2) family  1.A.21.1.3  
GO molecular function 
BH domain bindingdefinition[GO:0051400] silver  
1
  • Ortholog Compara
Chaperone bindingdefinition[GO:0051087] silver  
1
  • Ortholog Compara
Heat shock protein bindingdefinition[GO:0031072] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802]  
5
  • IntAct
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
20
  • IntAct
  • BHF-UCL
  • HGNC
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • RefGenome
GO biological process 
Activation of cysteine-type endopeptidase activitydefinition[GO:0097202]  
1
  • BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cdefinition[GO:0008635] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Apoptotic process involved in patterning of blood vesselsdefinition[GO:1902262] silver  
1
  • Ortholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • UniProtKB
B cell apoptotic processdefinition[GO:0001783] silver  
1
  • Ortholog Compara
B cell homeostasisdefinition[GO:0001782] silver  
1
  • Ortholog Compara
B cell negative selectiondefinition[GO:0002352] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
2
  • UniProtKB
  • Ortholog Curator
Endocrine pancreas developmentdefinition[GO:0031018] silver  
1
  • Ortholog Compara
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
1
  • UniProtKB
Establishment or maintenance of transmembrane electrochemical gradientdefinition[GO:0010248]  
1
  • HGNC
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
1
  • RefGenome
Fibroblast apoptotic processdefinition[GO:0044346] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • RefGenome
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
1
  • Ortholog Compara
Limb morphogenesisdefinition[GO:0035108] silver  
1
  • Ortholog Compara
Mitochondrial fusiondefinition[GO:0008053] silver  
1
  • Ortholog Compara
Myeloid cell homeostasisdefinition[GO:0002262] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032471] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137] silver  
1
  • Ortholog Compara
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524] silver  
1
  • Ortholog Compara
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • UniProtKB
Positive regulation of proteolysisdefinition[GO:0045862]  
1
  • BHF-UCL
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200] silver  
1
  • Ortholog Compara
Post-embryonic camera-type eye morphogenesisdefinition[GO:0048597] silver  
1
  • Ortholog Compara
Regulation of cell cycledefinition[GO:0051726] silver  
1
  • Ortholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
2
  • BHF-UCL
  • HGNC
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • HGNC
Regulation of protein heterodimerization activitydefinition[GO:0043497]  
1
  • HGNC
Regulation of protein homodimerization activitydefinition[GO:0043496]  
1
  • HGNC
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
3
  • BHF-UCL
  • HGNC
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to fungusdefinition[GO:0009620] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to mycotoxindefinition[GO:0010046] silver  
1
  • Ortholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Response to UV-Cdefinition[GO:0010225] silver  
1
  • Ortholog Compara
Thymocyte apoptotic processdefinition[GO:0070242] silver  
1
  • Ortholog Compara
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+578  
According to Reactome, this protein belongs to the following pathway:
Activation and oligomerization of BAK protein  REACT_707  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links