AANAT - Serotonin N-acetyltransferase - human protein (Function)
 
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AANAT »  Serotonin N-acetyltransferase   [ EC 2.3.1.87 ]  (Serotonin acetylase)
 
Protein also known as:  Aralkylamine N-acetyltransferase (AA-NAT).
Gene name:  AANAT
Family name: Acetyltransferase » AANAT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.  
1
  • UniProtKB
GO molecular function 
14-3-3 protein bindingdefinition[GO:0071889] silver  
1
  • Ortholog Compara
Aralkylamine N-acetyltransferase activitydefinition[GO:0004059]  
2
  • UniProtKB
Arylamine N-acetyltransferase activitydefinition[GO:0004060] silver  
1
  • Ortholog Compara
GO biological process 
Cellular response to cAMPdefinition[GO:0071320]  
1
  • UniProtKB
Circadian rhythmdefinition[GO:0007623]  
2
  • UniProtKB
Melatonin biosynthetic processdefinition[GO:0030187]  
3
  • UniProtKB
  • UniPathway
N-terminal protein amino acid acetylationdefinition[GO:0006474]  
1
  • UniProtKB
Response to calcium iondefinition[GO:0051592] silver  
1
  • Ortholog Compara
Response to copper iondefinition[GO:0046688] silver  
1
  • Ortholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
1
  • Ortholog Compara
Response to cytokinedefinition[GO:0034097] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to light stimulusdefinition[GO:0009416] silver  
1
  • Ortholog Compara
Response to prostaglandin Edefinition[GO:0034695] silver  
1
  • Ortholog Compara
Response to zinc iondefinition[GO:0010043] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.87: Acetyl-CoA + a 2-arylethylamine CoA + an N-acetyl-2-arylethylamine.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+15  
Tryptophan metabolism  hsa00380+15  
According to Reactome, this protein belongs to the following pathway:
Serotonin and melatonin biosynthesis  REACT_15439  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 2.6 mM for 5-hydroxytryptamine
KM 0.13 mM for tryptamine
KM 0.55 mM for phenylethylamine
KM 10.6 mM for tyramine

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Melatonin biosynthesis  definition   [KW-0471]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 15
PRO: PR:Q16613