AANAT - Serotonin N-acetyltransferase - human protein (Function)
 
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References

 
AANAT »  Serotonin N-acetyltransferase   [ EC 2.3.1.87 ]  (Serotonin acetylase)
 
Protein also known as:  Aralkylamine N-acetyltransferase (AA-NAT).
Gene name:  AANAT
Family name: Acetyltransferase » AANAT
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 12 1
GENE REF ISO

Function

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Overview 
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.  
  • CuratedUniProtKB
GO molecular function 
Aralkylamine N-acetyltransferase activitydefinition[GO:0004059]  
2
  • IDAUniProtKB
GO biological process 
Cellular response to cAMPdefinition[GO:0071320]  
1
  • IDAUniProtKB
Circadian rhythmdefinition[GO:0007623]  
2
  • IMPUniProtKB
Melatonin biosynthetic processdefinition[GO:0030187]  
2
  • IDAUniProtKB
  • IEAUniPathway
N-terminal protein amino acid acetylationdefinition[GO:0006474]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.87: Acetyl-CoA + a 2-arylethylamine CoA + an N-acetyl-2-arylethylamine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+15  
Tryptophan metabolism  hsa00380+15  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 2.6 mM for 5-hydroxytryptamine
KM 0.13 mM for tryptamine
KM 0.55 mM for phenylethylamine
KM 10.6 mM for tyramine

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Melatonin biosynthesis  definition   [KW-0471]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 15
PRO: PR:Q16613