CTF1 - Cardiotrophin-1 - human protein (Function)
 
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Gene
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CTF1 »  Cardiotrophin-1  (CT-1)
 
Gene name:  CTF1
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • UniProtKB KW
Leukemia inhibitory factor receptor bindingdefinition[GO:0005146] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Leukemia inhibitory factor signaling pathwaydefinition[GO:0048861] silver  
1
  • Ortholog Compara
Muscle organ developmentdefinition[GO:0007517]  
2
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Neuron developmentdefinition[GO:0048666] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517] silver  
1
  • CACAO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+1489  
Jak-STAT signaling pathway  hsa04630+1489  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1489
PRO: PR:Q16619