PDK4 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial - human protein (Function)
 
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PDK4 »  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial   [ EC 2.7.11.2 ]
 
Protein also known as:  Pyruvate dehydrogenase kinase isoform 4.
Gene name:  PDK4
Entry whose protein(s) existence is based on evidence at protein level
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1 30 1
GENE REF ISO

Function

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Overview 
Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Pyruvate dehydrogenase (acetyl-transferring) kinase activitydefinition[GO:0004740]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to fatty aciddefinition[GO:0071398]  
1
  • IMPUniProtKB
Cellular response to starvationdefinition[GO:0009267]  
1
  • IDAUniProtKB
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Glucose metabolic processdefinition[GO:0006006]  
  • IEAUniProtKB KW
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • IMPUniProtKB
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAGOC
  • ISSOrtholog Curator
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IMPUniProtKB
Regulation of acetyl-CoA biosynthetic process from pyruvatedefinition[GO:0010510]  
1
  • IMPUniProtKB
Regulation of bone resorptiondefinition[GO:0045124] silver  
  • IEAOrtholog Compara
Regulation of cellular ketone metabolic processdefinition[GO:0010565]  
  • ISSOrtholog Curator
Regulation of fatty acid biosynthetic processdefinition[GO:0042304]  
1
  • IMPUniProtKB
Regulation of fatty acid oxidationdefinition[GO:0046320]  
  • ISSOrtholog Curator
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • IMPUniProtKB
Regulation of pHdefinition[GO:0006885]  
  • ISSOrtholog Curator
Response to starvationdefinition[GO:0042594]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.2: ATP + [pyruvate dehydrogenase (acetyl-transferring)] ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDK4
GenomeRNAi: 5166
PRO: PR:Q16654