PDK4 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PDK4 »  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial   [ EC 2.7.11.2 ]
 
Protein also known as:  Pyruvate dehydrogenase kinase isoform 4.
Gene name:  PDK4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

 show evidences
Overview 
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.  
5
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Pyruvate dehydrogenase (acetyl-transferring) kinase activitydefinition[GO:0004740]  
1
  • Ortholog Curator
GO biological process 
Cellular response to fatty aciddefinition[GO:0071398]  
1
  • UniProtKB
Cellular response to starvationdefinition[GO:0009267]  
1
  • UniProtKB
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Glucose metabolic processdefinition[GO:0006006]  
1
  • UniProtKB KW
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • UniProtKB
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
4
  • GOC
  • EC 2 GO
  • Ortholog Curator
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • UniProtKB
Regulation of acetyl-CoA biosynthetic process from pyruvatedefinition[GO:0010510]  
1
  • UniProtKB
Regulation of bone resorptiondefinition[GO:0045124] silver  
1
  • Ortholog Compara
Regulation of cellular ketone metabolic processdefinition[GO:0010565]  
1
  • Ortholog Curator
Regulation of fatty acid biosynthetic processdefinition[GO:0042304]  
1
  • UniProtKB
Regulation of fatty acid oxidationdefinition[GO:0046320]  
1
  • Ortholog Curator
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • UniProtKB
Regulation of pHdefinition[GO:0006885]  
1
  • Ortholog Curator
Response to starvationdefinition[GO:0042594]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.2: ATP + [pyruvate dehydrogenase (acetyl-transferring)] ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDK4
GenomeRNAi: 5166
PRO: PR:Q16654