HIF1A - Hypoxia-inducible factor 1-alpha - human protein (Function)
 
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HIF1A »  Hypoxia-inducible factor 1-alpha  (HIF1-alpha)
 
Protein also known as:  Class E basic helix-loop-helix protein 78 (bHLHe78).
Gene name:  HIF1A
Entry whose protein(s) existence is based on evidence at protein level
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1 1570 3
GENE REF ISO

Function

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Overview 
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.  
9
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Histone acetyltransferase bindingdefinition[GO:0035035]  
1
  • IPIUniProtKB
Histone deacetylase bindingdefinition[GO:0042826] silver  
  • IEAOrtholog Compara
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Nuclear hormone receptor bindingdefinition[GO:0035257]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
30
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
3
  • TASUniProtKB
  • IPIBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
4
  • IDABHF-UCL
RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0001076] silver  
  • IEAOrtholog Compara
Contributes to sequence-specific DNA bindingdefinition[GO:0043565]  
3
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • IDAUniProtKB
  • IDAMGI
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription factor binding transcription factor activitydefinition[GO:0000989]  
1
  • IDABHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Axon transport of mitochondriondefinition[GO:0019896]  
1
  • IMPUniProtKB
B-1 B cell homeostasisdefinition[GO:0001922] silver  
  • IEAOrtholog Compara
Cardiac ventricle morphogenesisdefinition[GO:0003208] silver  
  • IEAOrtholog Compara
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Cellular iron ion homeostasisdefinition[GO:0006879] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456]  
4
  • IDAUniProtKB
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IEPBHF-UCL
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
Collagen metabolic processdefinition[GO:0032963]  
1
  • ISSBHF-UCL
Connective tissue replacement involved in inflammatory response wound healingdefinition[GO:0002248]  
1
  • ISSBHF-UCL
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
  • IEAOrtholog Compara
Elastin metabolic processdefinition[GO:0051541]  
1
  • ISSBHF-UCL
Embryonic hemopoiesisdefinition[GO:0035162] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Epithelial cell differentiation involved in mammary gland alveolus developmentdefinition[GO:0061030] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • ISSBHF-UCL
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Heart loopingdefinition[GO:0001947] silver  
  • IEAOrtholog Compara
Hemoglobin biosynthetic processdefinition[GO:0042541] silver  
  • IEAOrtholog Compara
Intestinal epithelial cell maturationdefinition[GO:0060574] silver  
  • IEAOrtholog Compara
Lactate metabolic processdefinition[GO:0006089] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789]  
1
  • ICBHF-UCL
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Negative regulation of bone mineralizationdefinition[GO:0030502] silver  
  • IEAOrtholog Compara
Negative regulation of growthdefinition[GO:0045926] silver  
  • IEAOrtholog Compara
Negative regulation of mesenchymal cell apoptotic processdefinition[GO:2001054] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of thymocyte apoptotic processdefinition[GO:0070244] silver  
  • IEAOrtholog Compara
Negative regulation of TOR signalingdefinition[GO:0032007] silver  
  • IEAOrtholog Compara
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Neural fold elevation formationdefinition[GO:0021502] silver  
  • IEAOrtholog Compara
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Oxygen homeostasisdefinition[GO:0032364]  
1
  • IDAHGNC
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • ICBHF-UCL
Positive regulation of chemokine productiondefinition[GO:0032722]  
1
  • TASBHF-UCL
Positive regulation of chemokine-mediated signaling pathwaydefinition[GO:0070101]  
1
  • ICBHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • ICBHF-UCL
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • ISSBHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • ICBHF-UCL
Positive regulation of glycolytic processdefinition[GO:0045821]  
1
  • ICBHF-UCL
Positive regulation of hormone biosynthetic processdefinition[GO:0046886]  
1
  • IDABHF-UCL
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774] silver  
  • IEAOrtholog Compara
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
  • IEAOrtholog Compara
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • TASBHF-UCL
Positive regulation of receptor biosynthetic processdefinition[GO:0010870]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IGIMGI
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxiadefinition[GO:0061419]  
2
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IMPUniProtKB
  • IDABHF-UCL
Positive regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030949]  
2
  • ICBHF-UCL
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
2
  • IMPUniProtKB
  • IDABHF-UCL
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IDAUniProtKB
Regulation of transcription from RNA polymerase II promoter in response to oxidative stressdefinition[GO:0043619]  
2
  • IDABHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • IDAUniProtKB
  • IDAMGI
Regulation of transforming growth factor beta2 productiondefinition[GO:0032909]  
1
  • IMPBHF-UCL
Response to hypoxiadefinition[GO:0001666]  
6
  • IDAUniProtKB
  • IMPBHF-UCL
  • IDAMGI
Response to muscle activitydefinition[GO:0014850] silver  
  • IEAOrtholog Compara
Retina vasculature development in camera-type eyedefinition[GO:0061298] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • IMPBHF-UCL
Vascular endothelial growth factor productiondefinition[GO:0010573]  
1
  • IDABHF-UCL
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
mTOR signaling pathway  hsa04150+3091  
Pathways in cancer  hsa05200+3091  
Renal cell carcinoma  hsa05211+3091  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HIF1A
GenomeRNAi: 3091
PRO: PR:Q16665