AMHR2 - Anti-Muellerian hormone type-2 receptor - human protein (Function)
 
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AMHR2 »  Anti-Muellerian hormone type-2 receptor   [ EC 2.7.11.30 ]
 
Protein also known as:  Anti-Muellerian hormone type II receptor (AMH type II receptor).
Gene name:  AMHR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.  
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  • UniProtKB
GO molecular function 
Anti-Mullerian hormone receptor activitydefinition[GO:1990272] silver  
1
  • Ortholog Compara
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Hormone bindingdefinition[GO:0042562]  
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  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Receptor activitydefinition[GO:0004872]  
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  • UniProtKB
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
1
  • InterPro 2 GO
Transforming growth factor beta receptor activity, type IIdefinition[GO:0005026] silver  
1
  • Ortholog Compara
GO biological process 
Anti-Mullerian hormone signaling pathwaydefinition[GO:1990262] silver  
1
  • Ortholog Compara
Mullerian duct regressiondefinition[GO:0001880]  
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  • UniProtKB
Negative regulation of anti-Mullerian hormone signaling pathwaydefinition[GO:1902613] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
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  • InterPro 2 GO
Sex differentiationdefinition[GO:0007548]  
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  • UniProtKB
  • Ortholog Curator
Signal transductiondefinition[GO:0007165]  
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  • UniProtKB
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • InterPro 2 GO
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+)  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+269  
TGF-beta signaling pathway  hsa04350+269  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 269
PRO: PR:Q16671