CYP1B1 - Cytochrome P450 1B1 - human protein (Function)
 
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CYP1B1 »  Cytochrome P450 1B1   [ EC 1.14.14.1 ]
 
Protein also known as:  CYPIB1.
Gene name:  CYP1B1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 214 1
GENE REF ISO

Function

 show evidences
Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.  
2
  • CuratedUniProtKB
Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.  
2
  • CuratedUniProtKB
GO molecular function 
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Heme bindingdefinition[GO:0020037]  
2
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Monooxygenase activitydefinition[GO:0004497]  
1
  • TASUniProtKB
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygendefinition[GO:0016712]  
1
  • IDAMGI
Oxygen bindingdefinition[GO:0019825]  
1
  • TASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Blood vessel morphogenesisdefinition[GO:0048514]  
  • ISSOrtholog Curator
Cellular aromatic compound metabolic processdefinition[GO:0006725] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • IDAMGI
Endothelial cell migrationdefinition[GO:0043542] silver  
  • IEAOrtholog Compara
Endothelial cell-cell adhesiondefinition[GO:0071603] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631]  
  • ISSOrtholog Curator
Negative regulation of cell adhesion mediated by integrindefinition[GO:0033629]  
  • ISSOrtholog Curator
Negative regulation of cell migrationdefinition[GO:0030336]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285]  
  • ISSOrtholog Curator
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
  • ISSOrtholog Curator
Positive regulation of gene expression involved in extracellular matrix organizationdefinition[GO:1901313]  
  • ISSOrtholog Curator
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
  • ISSOrtholog Curator
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
  • ISSOrtholog Curator
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Retina vasculature development in camera-type eyedefinition[GO:0061298] silver  
  • IEAOrtholog Compara
Steroid metabolic processdefinition[GO:0008202]  
1
  • IDAUniProtKB
Toxin metabolic processdefinition[GO:0009404] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601]  
1
  • TASUniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
2
  • CuratedUniProtKB
It requires the following cofactor
Heme group.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Enzyme activity is increased by liposomes containing anionic phospholipids, phosphatidic acid and cardiolipin.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolism of xenobiotics by cytochrome P450  hsa00980+1545  
Steroid hormone biosynthesis  hsa00140+1545  
Tryptophan metabolism  hsa00380+1545  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 24.0 uM for progesterone
KM 6.0 uM for 17-beta-estradiol
KM 17.0 uM for testosterone
Vmax 36.16 nmol/min/mg enzyme for testosterone 6-beta-hydroxylation
Vmax 14.95 nmol/min/mg enzyme for 17-beta-estradiol 4-hydroxylation
Vmax 6.9 nmol/min/mg enzyme for 17-beta-estradiol 2-hydroxylation
Vmax 37.80 nmol/min/mg enzyme for progesterone 16-alpha-hydroxylation
Vmax 9.86 nmol/min/mg enzyme for progesterone 6-beta-hydroxylation

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16678
Other
GeneWiki: CYP1B1
GenomeRNAi: 1545
PRO: PR:Q16678