DECR1 - 2,4-dienoyl-CoA reductase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
DECR1 »  2,4-dienoyl-CoA reductase, mitochondrial   [ EC 1.3.1.34 ]
 
Protein also known as:  2,4-dienoyl-CoA reductase [NADPH] (4-enoyl-CoA reductase [NADPH]).
Gene name:  DECR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.  
  • CuratedUniProtKB
GO molecular function 
2,4-dienoyl-CoA reductase (NADPH) activitydefinition[GO:0008670]  
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  • IDAUniProtKB
NADPH bindingdefinition[GO:0070402]  
1
  • IDAUniProtKB
GO biological process 
Fatty acid beta-oxidationdefinition[GO:0006635]  
1
  • IDAUniProtKB
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.1.34: Trans-2,3-didehydroacyl-CoA + NADP(+) trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 7.7 uM for NADPH
KM 14.3 uM for trans-2,trans-4-hexadienoyl-CoA
Vmax 30.3 umol/min/mg enzyme

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16698
Other
GenomeRNAi: 1666
PRO: PR:Q16698