MAN2A1 - Alpha-mannosidase 2 - human protein (Function)
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MAN2A1 »  Alpha-mannosidase 2   [ EC ]
Protein also known as:  Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase.
Gene name:  MAN2A1
Family name: Glycosyl hydrolase 38
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.  
  • CuratedUniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Hydrolase activity, hydrolyzing N-glycosyl compoundsdefinition[GO:0016799] silver  
  • IEAOrtholog Compara
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activitydefinition[GO:0004572]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IEAOrtholog Compara
Mannose metabolic processdefinition[GO:0006013] silver  
  • IEAInterPro 2 GO
Mitochondrion organizationdefinition[GO:0007005] silver  
  • IEAOrtholog Compara
N-glycan processingdefinition[GO:0006491] silver  
  • IEAOrtholog Compara
Positive regulation of neurogenesisdefinition[GO:0050769] silver  
  • IEAOrtholog Compara
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Retina morphogenesis in camera-type eyedefinition[GO:0060042] silver  
  • IEAOrtholog Compara
Vacuole organizationdefinition[GO:0007033] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 38  GH38  
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+4124  
N-Glycan biosynthesis  hsa00510+4124  
According to Reactome, this protein belongs to the following pathway:
Reactions specific to the complex N-glycan synthesis pathway  REACT_25302  
More information is available from:


Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: MAN2A1
GenomeRNAi: 4124
PRO: PR:Q16706