ATP2B3 - Plasma membrane calcium-transporting ATPase 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ATP2B3 »  Plasma membrane calcium-transporting ATPase 3   [ EC 3.6.3.8 ]  (PMCA3)
 
Protein also known as:  Plasma membrane calcium ATPase isoform 3.
Gene name:  ATP2B3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 8
GENE REF ISO

Function

 show evidences
Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium-transporting ATPase activitydefinition[GO:0005388]  
  • IEAEC 2 GO
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+492  
Pancreatic secretion  hsa04972+492  
Salivary secretion  hsa04970+492  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2B3
GenomeRNAi: 492
PRO: PR:Q16720