CLPP - Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial - human protein (Function)
 
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CLPP »  Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial   [ EC 3.4.21.92 ]
 
Protein also known as:  Endopeptidase Clp.
Gene name:  CLPP
Family name: Peptidase S14
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Peptidase activitydefinition[GO:0008233]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.92: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLPP
GenomeRNAi: 8192
PRO: PR:Q16740