CLPP - ATP-dependent Clp protease proteolytic subunit, mitochondrial - human protein (Function)
 
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CLPP »  ATP-dependent Clp protease proteolytic subunit, mitochondrial   [ EC 3.4.21.92 ]
 
Protein also known as:  Endopeptidase Clp.
Gene name:  CLPP
Family name: Peptidase S14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.  
2
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Peptidase activitydefinition[GO:0008233]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • IDAUniProtKB
GO biological process 
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.92: Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).  
2
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLPP
GenomeRNAi: 8192
PRO: PR:Q16740