TST - Thiosulfate sulfurtransferase - human protein (Function)
 
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Protein
Gene
References

 
TST »  Thiosulfate sulfurtransferase   [ EC 2.8.1.1 ]
 
Protein also known as:  Rhodanese.
Gene name:  TST
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

 show evidences
Overview 
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.  
2
  • CuratedUniProtKB
GO molecular function 
5S rRNA bindingdefinition[GO:0008097]  
2
  • IDAUniProtKB
Thiosulfate sulfurtransferase activitydefinition[GO:0004792]  
  • IEAEC 2 GO
GO biological process 
Cyanate catabolic processdefinition[GO:0009440]  
1
  • TASPINC
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IDAUniProtKB
rRNA import into mitochondriondefinition[GO:0035928]  
1
  • IMPUniProtKB
rRNA transportdefinition[GO:0051029]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.1.1: Thiosulfate + cyanide sulfite + thiocyanate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+7263  
Metabolic pathways  hsa01100+7263  
Sulfur relay system  hsa04122+7263  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TST_(gene)
GenomeRNAi: 7263
PRO: PR:Q16762