UBE2S - Ubiquitin-conjugating enzyme E2 S - human protein (Function)
 
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References

 
UBE2S »  Ubiquitin-conjugating enzyme E2 S   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin-conjugating enzyme E2-24 kDa.
Gene name:  UBE2S
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.  
5
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Contributes to ubiquitin-protein transferase activitydefinition[GO:0004842]  
3
  • IDAUniProtKB
GO biological process 
Activation of anaphase-promoting complex activitydefinition[GO:0051488]  
2
  • IDAUniProtKB
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031145]  
2
  • IDAUniProtKB
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Exit from mitosisdefinition[GO:0010458]  
2
  • IDAUniProtKB
Free ubiquitin chain polymerizationdefinition[GO:0010994]  
1
  • IDAUniProtKB
Protein K11-linked ubiquitinationdefinition[GO:0070979]  
3
  • IDAUniProtKB
Protein K27-linked ubiquitinationdefinition[GO:0044314]  
1
  • IDAUniProtKB
Protein K29-linked ubiquitinationdefinition[GO:0035519]  
1
  • IDAUniProtKB
Protein K6-linked ubiquitinationdefinition[GO:0085020]  
1
  • IDAUniProtKB
Protein K63-linked ubiquitinationdefinition[GO:0070534]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
2
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+27338  
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 27338
PRO: PR:Q16763