CCBL1 - Kynurenine--oxoglutarate transaminase 1 - human protein (Function)
 
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CCBL1 »  Kynurenine--oxoglutarate transaminase 1   [ EC 2.6.1.7 ]
 
Protein also known as:  Kynurenine--oxoglutarate transaminase I.
Gene name:  CCBL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 3
GENE REF ISO

Function

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Overview 
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-S-conjugate beta-lyase activitydefinition[GO:0047804]  
  • IEAEC 2 GO
Glutamine-phenylpyruvate transaminase activitydefinition[GO:0047316]  
  • IEAEC 2 GO
Kynurenine-oxoglutarate transaminase activitydefinition[GO:0016212]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAInterPro 2 GO
Transaminase activitydefinition[GO:0008483]  
1
  • TASPINC
GO biological process 
Cellular modified amino acid metabolic processdefinition[GO:0006575]  
1
  • TASPINC
Kynurenine metabolic processdefinition[GO:0070189]  
1
  • IDAUniProtKB
L-kynurenine catabolic processdefinition[GO:0097053]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.7: L-kynurenine + 2-oxoglutarate 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.  
1
  • CuratedUniProtKB
EC 2.6.1.64: L-glutamine + phenylpyruvate 2-oxoglutaramate + L-phenylalanine.  
1
  • CuratedUniProtKB
EC 4.4.1.13: RS-CH(2)-CH(NH(3)(+))COO(-) + H(2)O RSH + NH(3) + pyruvate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC) and Tris.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+883  
Selenocompound metabolism  hsa00450+883  
Tryptophan metabolism  hsa00380+883  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Lyase  definition   [KW-0456]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CCBL1
GenomeRNAi: 883
PRO: PR:Q16773