HAGH - Hydroxyacylglutathione hydrolase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
HAGH »  Hydroxyacylglutathione hydrolase, mitochondrial   [ EC 3.1.2.6 ]
 
Protein also known as:  Glyoxalase II (Glx II).
Gene name:  HAGH
Entry whose protein(s) existence is based on evidence at protein level
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1 19 3
GENE REF ISO

Function

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Overview 
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.  
  • CuratedUniProtKB
GO molecular function 
Hydroxyacylglutathione hydrolase activitydefinition[GO:0004416]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Glutathione biosynthetic processdefinition[GO:0006750]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.2.6: S-(2-hydroxyacyl)glutathione + H(2)O glutathione + a 2-hydroxy carboxylate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Pyruvate metabolism  hsa00620+3029  
Caution 
Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16775
Other
GeneWiki: HAGH
GenomeRNAi: 3029
PRO: PR:Q16775