LAMA3 - Laminin subunit alpha-3 - human protein (Function)
 
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LAMA3 »  Laminin subunit alpha-3
 
Protein also known as:  Epiligrin 170 kDa subunit (E170).
Gene name:  LAMA3
Entry whose protein(s) existence is based on evidence at protein level
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1 85 4
GENE REF ISO

Function

 show evidences
Overview 
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.  
  • CuratedUniProtKB
Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.  
  • CuratedUniProtKB
GO molecular function 
Receptor bindingdefinition[GO:0005102] silver  
  • IEAInterPro 2 GO
Structural molecule activitydefinition[GO:0005198]  
1
  • NASPINC
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Epidermis developmentdefinition[GO:0008544]  
1
  • TASPINC
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAInterPro 2 GO
Regulation of cell migrationdefinition[GO:0030334] silver  
  • IEAInterPro 2 GO
Regulation of embryonic developmentdefinition[GO:0045995] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+3909  
ECM-receptor interaction  hsa04512+3909  
Focal adhesion  hsa04510+3909  
Pathways in cancer  hsa05200+3909  
Small cell lung cancer  hsa05222+3909  
Toxoplasmosis  hsa05145+3909  
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  REACT_150268  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Degradation of the extracellular matrix  REACT_118572  
ECM proteoglycans  REACT_163906  
Laminin interactions  REACT_169262  
Non-integrin membrane-ECM interactions  REACT_163874  
Type I hemidesmosome assembly  REACT_20537  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Laminin,_alpha_3
GenomeRNAi: 3909
PRO: PR:Q16787