CA9 - Carbonic anhydrase 9 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CA9 »  Carbonic anhydrase 9   [ EC 4.2.1.1 ]
 
Protein also known as:  Renal cell carcinoma-associated antigen G250 (RCC-associated antigen G250).
Gene name:  CA9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 169 1
GENE REF ISO

Function

 show evidences
Overview 
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.  
1
  • CuratedUniProtKB
GO molecular function 
Carbonate dehydratase activitydefinition[GO:0004089]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Morphogenesis of an epitheliumdefinition[GO:0002009] silver  
  • IEAOrtholog Compara
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Secretiondefinition[GO:0046903] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).  
4
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nitrogen metabolism  hsa00910+768  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Metabolism  REACT_111217  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 6.5.

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Carbonic_anhydrase_9
GenomeRNAi: 768
PRO: PR:Q16790