PHKG1 - Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform - human protein (Function)
 
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PHKG1 »  Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform   [ EC 2.7.11.19 ]  (PHK-gamma-M)
 
Protein also known as:  Serine/threonine-protein kinase PHKG1 [EC 2.7.11.1EC 2.7.11.26].
Gene name:  PHKG1
Entry whose protein(s) existence is based on evidence at transcript level
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1 18 2
GENE REF ISO

Function

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Overview 
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Phosphorylase kinase activitydefinition[GO:0004689]  
  • IEAEC 2 GO
Tau-protein kinase activitydefinition[GO:0050321]  
  • IEAEC 2 GO
GO biological process 
Glycogen biosynthetic processdefinition[GO:0005978] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.19: 2 ATP + phosphorylase b 2 ADP + phosphorylase a.  
  • CuratedUniProtKB
EC 2.7.11.26: ATP + [tau protein] ADP + [tau protein] phosphate.  
  • CuratedUniProtKB
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5260  
Insulin signaling pathway  hsa04910+5260  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glycogen metabolism  definition   [KW-0321]
Molecular function 
Kinase  definition   [KW-0418]
Muscle protein  definition   [KW-0514]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PHKG1
GenomeRNAi: 5260
PRO: PR:Q16816
Chemistry
GuidetoPHARMACOLOGY: 2145