PTPRO - Receptor-type tyrosine-protein phosphatase O - human protein (Function)
 
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PTPRO »  Receptor-type tyrosine-protein phosphatase O   [ EC 3.1.3.48 ]  (R-PTP-O)
 
Protein also known as:  Glomerular epithelial protein 1.
Gene name:  PTPRO
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Phosphatase activitydefinition[GO:0016791]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
3
  • IMPUniProtKB
Transmembrane receptor protein tyrosine phosphatase activitydefinition[GO:0005001]  
1
  • NASUniProtKB
Wnt-protein bindingdefinition[GO:0017147]  
  • ISSOrtholog Curator
GO biological process 
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Cell morphogenesisdefinition[GO:0000902]  
  • ISSOrtholog Curator
Glomerular visceral epithelial cell differentiationdefinition[GO:0072112]  
  • ISSOrtholog Curator
Glomerulus developmentdefinition[GO:0032835]  
1
  • IMPUniProtKB
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • IMPUniProtKB
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
  • ISSOrtholog Curator
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
  • ISSOrtholog Curator
Negative regulation of glomerular filtrationdefinition[GO:0003105]  
  • ISSOrtholog Curator
Negative regulation of neuron projection developmentdefinition[GO:0010977]  
  • ISSOrtholog Curator
Negative regulation of retinal ganglion cell axon guidancedefinition[GO:0090260]  
  • ISSOrtholog Curator
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • IMPUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Regulation of glomerular filtrationdefinition[GO:0003093]  
  • ISSOrtholog Curator
Slit diaphragm assemblydefinition[GO:0036060]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTPRO
GenomeRNAi: 5800
PRO: PR:Q16827