DDR2 - Discoidin domain-containing receptor 2 - human protein (Function)
 
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DDR2 »  Discoidin domain-containing receptor 2   [ EC 2.7.10.1 ]  (Discoidin domain receptor 2)
 
Protein also known as:  Discoidin domain-containing receptor tyrosine kinase 2; CD antigen CD167b.
Gene name:  DDR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.  
9
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Collagen bindingdefinition[GO:0005518]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein tyrosine kinase collagen receptor activitydefinition[GO:0038062]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • UniProtKB
GO biological process 
Biomineral tissue developmentdefinition[GO:0031214]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Chondrocyte proliferationdefinition[GO:0035988]  
2
  • UniProtKB
  • Ortholog Curator
Collagen fibril organizationdefinition[GO:0030199]  
1
  • Ortholog Curator
Collagen-activated tyrosine kinase receptor signaling pathwaydefinition[GO:0038063]  
1
  • UniProtKB
Endochondral bone growthdefinition[GO:0003416]  
1
  • Ortholog Curator
Ossificationdefinition[GO:0001503]  
1
  • UniProtKB KW
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB
Positive regulation of extracellular matrix disassemblydefinition[GO:0090091]  
1
  • Ortholog Curator
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • Ortholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • UniProtKB
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • UniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Regulation of bone mineralizationdefinition[GO:0030500]  
1
  • UniProtKB
Regulation of extracellular matrix disassemblydefinition[GO:0010715]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
4
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Non-integrin membrane-ECM interactions  REACT_163874  
 

Keywords

Biological process 
Osteogenesis  definition   [KW-0892]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Discoidin_domain-containing_receptor_2
GenomeRNAi: 4921
PRO: PR:Q16832
Chemistry
GuidetoPHARMACOLOGY: 1844