DDR2 - Discoidin domain-containing receptor 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
DDR2 »  Discoidin domain-containing receptor 2   [ EC 2.7.10.1 ]  (Discoidin domain receptor 2)
 
Protein also known as:  Discoidin domain-containing receptor tyrosine kinase 2; CD antigen CD167b.
Gene name:  DDR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 90 1
GENE REF ISO

Function

 show evidences
Overview 
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Collagen bindingdefinition[GO:0005518]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein tyrosine kinase collagen receptor activitydefinition[GO:0038062]  
1
  • IDAUniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • IDAUniProtKB
GO biological process 
Biomineral tissue developmentdefinition[GO:0031214]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155] silver  
  • IEAInterPro 2 GO
Chondrocyte proliferationdefinition[GO:0035988]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Collagen fibril organizationdefinition[GO:0030199]  
  • ISSOrtholog Curator
Collagen-activated tyrosine kinase receptor signaling pathwaydefinition[GO:0038063]  
1
  • IDAUniProtKB
Endochondral bone growthdefinition[GO:0003416]  
  • ISSOrtholog Curator
Ossificationdefinition[GO:0001503]  
  • IEAUniProtKB KW
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAUniProtKB
Positive regulation of extracellular matrix disassemblydefinition[GO:0090091]  
  • ISSOrtholog Curator
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
  • ISSOrtholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPUniProtKB
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IMPUniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of bone mineralizationdefinition[GO:0030500]  
1
  • IMPUniProtKB
Regulation of extracellular matrix disassemblydefinition[GO:0010715]  
1
  • TASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Non-integrin membrane-ECM interactions  REACT_163874  
 

Keywords

Biological process 
Osteogenesis  definition   [KW-0892]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Discoidin_domain-containing_receptor_2
GenomeRNAi: 4921
PRO: PR:Q16832
Chemistry
GuidetoPHARMACOLOGY: 1844