HADH - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
HADH »  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial  (HCDH)
 
Protein also known as:  Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase.
Gene name:  HADH
One or more isoforms of this protein have been shown to exist at protein level
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1 23 2
GENE REF ISO

Function

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Overview 
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.  
  • CuratedUniProtKB
GO molecular function 
NAD+ bindingdefinition[GO:0070403] silver  
  • IEAInterPro 2 GO
GO biological process 
Fatty acid beta-oxidationdefinition[GO:0006635]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.35: (S)-3-hydroxyacyl-CoA + NAD(+) 3-oxoacyl-CoA + NADH.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+3033  
Fatty acid elongation  hsa00062+3033  
Fatty acid metabolism  hsa00071+3033  
Lysine degradation  hsa00310+3033  
Metabolic pathways  hsa01100+3033  
Tryptophan metabolism  hsa00380+3033  
Valine, leucine and isoleucine degradation  hsa00280+3033  
According to Pathway Interaction DB, this protein belongs to the following pathway:
FOXA2 and FOXA3 transcription factor networks  hnf3bpathway  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]