HADH - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial - human protein (Function)
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HADH »  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial   [ EC ]  (HCDH)
Protein also known as:  Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase.
Gene name:  HADH
Entry whose protein(s) existence is based on evidence at protein level
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Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.  
  • CuratedUniProtKB
GO molecular function 
NAD+ bindingdefinition[GO:0070403] silver  
  • IEAInterPro 2 GO
GO biological process 
Fatty acid beta-oxidationdefinition[GO:0006635]  
  • IEAUniPathway
Negative regulation of insulin secretiondefinition[GO:0046676] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC (S)-3-hydroxyacyl-CoA + NAD(+) 3-oxoacyl-CoA + NADH.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+3033  
Fatty acid elongation  hsa00062+3033  
Fatty acid metabolism  hsa00071+3033  
Lysine degradation  hsa00310+3033  
Metabolic pathways  hsa01100+3033  
Tryptophan metabolism  hsa00380+3033  
Valine, leucine and isoleucine degradation  hsa00280+3033  
According to Reactome, this protein belongs to the following pathways:
Beta oxidation of butanoyl-CoA to acetyl-CoA  REACT_419  
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA  REACT_1708  
Beta oxidation of hexanoyl-CoA to butanoyl-CoA  REACT_1887  
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA  REACT_735  
Beta oxidation of octanoyl-CoA to hexanoyl-CoA  REACT_1697  
More information is available from:


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: Q16836
GeneWiki: Hydroxyacyl-Coenzyme_A_dehydrogenase
GenomeRNAi: 3033
PRO: PR:Q16836