AOC3 - Membrane primary amine oxidase - human protein (Function)
 
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AOC3 »  Membrane primary amine oxidase   [ EC 1.4.3.21 ]
 
Protein also known as:  Semicarbazide-sensitive amine oxidase (SSAO).
Gene name:  AOC3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.  
5
  • UniProtKB
GO molecular function 
Aliphatic-amine oxidase activitydefinition[GO:0052595]  
1
  • EC 2 GO
Aminoacetone:oxygen oxidoreductase(deaminating) activitydefinition[GO:0052594]  
1
  • EC 2 GO
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • UniProtKB
Copper ion bindingdefinition[GO:0005507]  
1
  • UniProtKB
Phenethylamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052596]  
1
  • EC 2 GO
Primary amine oxidase activitydefinition[GO:0008131]  
3
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Quinone bindingdefinition[GO:0048038]  
1
  • UniProtKB
Tryptamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052593]  
1
  • EC 2 GO
GO biological process 
Amine metabolic processdefinition[GO:0009308]  
1
  • UniProtKB
Cation transmembrane transportdefinition[GO:0098655]  
1
  • GOC
Cation transportdefinition[GO:0006812]  
1
  • GOC
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Response to antibioticdefinition[GO:0046677]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.4.3.21: RCH(2)NH(2) + H(2)O + O(2) RCHO + NH(3) + H(2)O(2).  
1
  • UniProtKB
EC 1.4.3.21: RCH(2)NH(2) + H(2)O + O(2) RCHO + NH(3) + H(2)O(2).  
1
  • UniProtKB
It requires the following cofactors
 Cu cation : Binds 1 copper ion per subunit.  
1
  • UniProtKB
 Ca(2+) : Binds 2 calcium ions per subunit.  
1
  • UniProtKB
 L-topaquinone : Contains 1 topaquinone per subunit.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+8639  
Glycine, serine and threonine metabolism  hsa00260+8639  
Metabolic pathways  hsa01100+8639  
Phenylalanine metabolism  hsa00360+8639  
Tyrosine metabolism  hsa00350+8639  
 

Biophysicochemical properties

Kinetic parameters
KM 1.94 mM for 2-phenylethylamine
KM 0.67 mM for methylamine

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16853
Other
GeneWiki: AOC3
GenomeRNAi: 8639
PRO: PR:Q16853
Chemistry
GuidetoPHARMACOLOGY: 2767