AOC3 - Membrane primary amine oxidase - human protein (Function)
 
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AOC3 »  Membrane primary amine oxidase   [ EC 1.4.3.21 ]
 
Protein also known as:  Semicarbazide-sensitive amine oxidase (SSAO).
Gene name:  AOC3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 85 3
GENE REF ISO

Function

 show evidences
Overview 
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.  
4
  • CuratedUniProtKB
GO molecular function 
Aliphatic-amine oxidase activitydefinition[GO:0052595]  
  • IEAEC 2 GO
Aminoacetone:oxygen oxidoreductase(deaminating) activitydefinition[GO:0052594]  
  • IEAEC 2 GO
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Cation channel activitydefinition[GO:0005261]  
1
  • IDAUniProtKB
Copper ion bindingdefinition[GO:0005507]  
1
  • IDAUniProtKB
Phenethylamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052596]  
  • IEAEC 2 GO
Primary amine oxidase activitydefinition[GO:0008131]  
3
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • TASUniProtKB
Quinone bindingdefinition[GO:0048038]  
1
  • IDAUniProtKB
Tryptamine:oxygen oxidoreductase (deaminating) activitydefinition[GO:0052593]  
  • IEAEC 2 GO
GO biological process 
Amine metabolic processdefinition[GO:0009308]  
1
  • IDAUniProtKB
Cation transportdefinition[GO:0006812]  
1
  • IDAGOC
Cell adhesiondefinition[GO:0007155]  
1
  • IDAUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Response to antibioticdefinition[GO:0046677]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.3.21: RCH(2)NH(2) + H(2)O + O(2) RCHO + NH(3) + H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 copper ion per subunit.  
  • CuratedUniProtKB
Binds 2 calcium ions per subunit.  
  • CuratedUniProtKB
Contains 1 topaquinone per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+8639  
Glycine, serine and threonine metabolism  hsa00260+8639  
Metabolic pathways  hsa01100+8639  
Phenylalanine metabolism  hsa00360+8639  
Tyrosine metabolism  hsa00350+8639  
 

Biophysicochemical properties

Kinetic parameters
KM 1.94 mM for 2-phenylethylamine
KM 0.67 mM for methylamine

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16853
Other
GeneWiki: AOC3
GenomeRNAi: 8639
PRO: PR:Q16853
Chemistry
GuidetoPHARMACOLOGY: 2767