DGUOK - Deoxyguanosine kinase, mitochondrial - human protein (Function)
 
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DGUOK »  Deoxyguanosine kinase, mitochondrial   [ EC 2.7.1.113 ]  (dGK)
 
Gene name:  DGUOK
Family name: DCK/DGK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Deoxyguanosine kinase activitydefinition[GO:0004138]  
1
  • IDAUniProtKB
Phosphotransferase activity, alcohol group as acceptordefinition[GO:0016773] silver  
  • IEAInterPro 2 GO
GO biological process 
Deoxyribonucleoside monophosphate biosynthetic processdefinition[GO:0009157]  
2
  • IDAGOC
dGTP metabolic processdefinition[GO:0046070] silver  
  • IEAOrtholog Compara
Guanosine metabolic processdefinition[GO:0008617]  
1
  • TASPINC
Negative regulation of neuron projection developmentdefinition[GO:0010977] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Purine deoxyribonucleoside metabolic processdefinition[GO:0046122]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.113: ATP + deoxyguanosine ADP + dGMP.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1716  
Purine metabolism  hsa00230+1716  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16854
Other
GeneWiki: DGUOK
GenomeRNAi: 1716
PRO: PR:Q16854