ATP6V1F - V-type proton ATPase subunit F - human protein (Function)
 
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ATP6V1F »  V-type proton ATPase subunit F  (V-ATPase subunit F)
 
Protein also known as:  Vacuolar proton pump subunit F.
Gene name:  ATP6V1F
Family name: V-ATPase F subunit
Entry whose protein(s) existence is based on evidence at protein level
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1 17 2
GENE REF ISO

Function

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Overview 
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATPase activity, uncoupleddefinition[GO:0042624]  
1
  • NASUniProtKB
Hydrogen ion transmembrane transporter activitydefinition[GO:0015078]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Proton-transporting ATPase activity, rotational mechanismdefinition[GO:0046961] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • NASGOC
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Proton transportdefinition[GO:0015992]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+9296  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+9296  
Metabolic pathways  hsa01100+9296  
Oxidative phosphorylation  hsa00190+9296  
Phagosome  hsa04145+9296  
Rheumatoid arthritis  hsa05323+9296  
Synaptic vesicle cycle  hsa04721+9296  
Vibrio cholerae infection  hsa05110+9296  
According to Reactome, this protein belongs to the following pathways:
Insulin receptor recycling  REACT_1109  
Phagosomal maturation (early endosomal stage)  REACT_121256  
Transferrin endocytosis and recycling  REACT_25283  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V1F
GenomeRNAi: 9296
PRO: PR:Q16864