LTC4S - Leukotriene C4 synthase - human protein (Function)
 
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LTC4S »  Leukotriene C4 synthase   [ EC 4.4.1.20 ]  (LTC4 synthase)
 
Protein also known as:  Leukotriene-C(4) synthase.
Gene name:  LTC4S
Family name: MAPEG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.  
  • CuratedUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.4.1.20: Leukotriene C(4) leukotriene A(4) + glutathione.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+4056  
Metabolic pathways  hsa01100+4056  
According to Reactome, this protein belongs to the following pathways:
Synthesis of 5-eicosatetraenoic acids  REACT_150209  
Synthesis of Leukotrienes (LT) and Eoxins (EX)  REACT_150420  
Synthesis of Lipoxins (LX)  REACT_150320  
 
More information is available from:
 

Keywords

Biological process 
Leukotriene biosynthesis  definition   [KW-0434]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16873
Other
GeneWiki: Leukotriene_C4_synthase
GenomeRNAi: 4056
PRO: PR:Q16873