PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 - human protein (Function)
 
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PFKFB3 »  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3  (PFK/FBPase 3)
 
Protein also known as:  6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme.
Gene name:  PFKFB3
Family name: In the C-terminal section Phosphoglycerate mutase
Entry whose protein(s) existence is based on evidence at protein level
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1 73 4
GENE REF ISO

Function

 show evidences
Overview 
Synthesis and degradation of fructose 2,6-bisphosphate.  
  • CuratedUniProtKB
GO molecular function 
6-phosphofructo-2-kinase activitydefinition[GO:0003873]  
1
  • NASUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Fructose-2,6-bisphosphate 2-phosphatase activitydefinition[GO:0004331]  
  • IEAEC 2 GO
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
1
  • NASGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Dephosphorylationdefinition[GO:0016311]  
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Fructose 2,6-bisphosphate metabolic processdefinition[GO:0006003] silver  
  • IEAInterPro 2 GO
Fructose metabolic processdefinition[GO:0006000] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.46: Beta-D-fructose 2,6-bisphosphate + H(2)O D-fructose 6-phosphate + phosphate.  
  • CuratedUniProtKB
EC 2.7.1.105: ATP + D-fructose 6-phosphate ADP + beta-D-fructose 2,6-bisphosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fructose and mannose metabolism  hsa00051+5209  
According to Reactome, this protein belongs to the following pathway:
Glycolysis  REACT_1383  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q16875
Other
GeneWiki: PFKFB3
GenomeRNAi: 5209
PRO: PR:Q16875