CDO1 - Cysteine dioxygenase type 1 - human protein (Function)
 
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CDO1 »  Cysteine dioxygenase type 1   [ EC 1.13.11.20 ]
 
Protein also known as:  Cysteine dioxygenase type I (CDO).
Gene name:  CDO1
Family name: Cysteine dioxygenase
Entry whose protein(s) existence is based on evidence at protein level
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1 28 1
GENE REF ISO

Function

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Overview 
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.  
  • CuratedUniProtKB
GO molecular function 
Cysteine dioxygenase activitydefinition[GO:0017172]  
  • ISSOrtholog Curator
Ferrous iron bindingdefinition[GO:0008198] silver  
  • IEAOrtholog Compara
GO biological process 
Cysteine metabolic processdefinition[GO:0006534]  
1
  • TASUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
L-cysteine catabolic processdefinition[GO:0019448] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to glucagondefinition[GO:0033762] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Sulfur amino acid biosynthetic processdefinition[GO:0000097]  
1
  • TASUniProtKB
Taurine biosynthetic processdefinition[GO:0042412]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.13.11.20: L-cysteine + O(2) 3-sulfinoalanine.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 iron ion per subunit. Zinc to a much lesser extent.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+1036  
Metabolic pathways  hsa01100+1036  
Taurine and hypotaurine metabolism  hsa00430+1036  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1036
PRO: PR:Q16878