CDO1 - Cysteine dioxygenase type 1 - human protein (Function)
 
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CDO1 »  Cysteine dioxygenase type 1   [ EC 1.13.11.20 ]
 
Protein also known as:  Cysteine dioxygenase type I (CDO).
Gene name:  CDO1
Family name: Cysteine dioxygenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.  
1
  • UniProtKB
GO molecular function 
Cysteine dioxygenase activitydefinition[GO:0017172]  
1
  • Ortholog Curator
Ferrous iron bindingdefinition[GO:0008198] silver  
1
  • Ortholog Compara
GO biological process 
Cysteine metabolic processdefinition[GO:0006534]  
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  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB
L-cysteine catabolic processdefinition[GO:0019448] silver  
1
  • Ortholog Compara
Lactationdefinition[GO:0007595] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to glucagondefinition[GO:0033762] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Sulfur amino acid biosynthetic processdefinition[GO:0000097]  
1
  • UniProtKB
Taurine biosynthetic processdefinition[GO:0042412]  
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  • UniProtKB
  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.13.11.20: L-cysteine + O(2) 3-sulfinoalanine.  
1
  • UniProtKB
It requires the following cofactor
 Fe(2+) : Binds 1 Fe(2+) cation per subunit. Zn(2+) can be used to a much lesser extent.  
1
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+1036  
Metabolic pathways  hsa01100+1036  
Taurine and hypotaurine metabolism  hsa00430+1036  
According to Reactome, this protein belongs to the following pathway:
Degradation of cysteine and homocysteine  REACT_115654  
 
More information is available from:
 

Keywords

Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1036
PRO: PR:Q16878