DOK7 - Protein Dok-7 - human protein (Function)
 
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DOK7 »  Protein Dok-7
 
Protein also known as:  Downstream of tyrosine kinase 7.
Gene name:  DOK7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.  
1
  • CuratedUniProtKB
GO molecular function 
Insulin receptor bindingdefinition[GO:0005158] silver  
  • IEAInterPro 2 GO
Phosphatidylinositol bindingdefinition[GO:0035091] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IDAUniProtKB
GO biological process 
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • IDAUniProtKB
Receptor clusteringdefinition[GO:0043113] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 285489
PRO: PR:Q18PE1