RSPO4 - R-spondin-4 - human protein (Function)
 
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Protein
Gene
References

 
RSPO4 »  R-spondin-4
 
Protein also known as:  Roof plate-specific spondin-4.
Gene name:  RSPO4
Family name: R-spondin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.  
3
  • UniProtKB
GO molecular function 
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • RefGenome
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
GO biological process 
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • RefGenome
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_264580  
Note 
Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed16357527).  
2
  • UniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 343637
PRO: PR:Q2I0M5