AAK1 - AP2-associated protein kinase 1 - human protein (Function)
 
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AAK1 »  AP2-associated protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Adaptor-associated kinase 1.
Gene name:  AAK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis.  
4
  • CuratedUniProtKB
Display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.  
4
  • CuratedUniProtKB
GO molecular function 
AP-2 adaptor complex bindingdefinition[GO:0035612]  
1
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Notch bindingdefinition[GO:0005112]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • ISSOrtholog Curator
GO biological process 
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAUniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • IDAUniProtKB
Regulation of clathrin-mediated endocytosisdefinition[GO:2000369]  
2
  • IDAUniProtKB
Regulation of protein localizationdefinition[GO:0032880]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Stimulated by clathrin (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AAK1
GenomeRNAi: 22848
PRO: PR:Q2M2I8
Chemistry
GuidetoPHARMACOLOGY: 1921