ABCB5 - ATP-binding cassette sub-family B member 5 - human protein (Function)
 
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ABCB5 »  ATP-binding cassette sub-family B member 5
 
Protein also known as:  P-glycoprotein ABCB5.
Gene name:  ABCB5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.13  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
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  • RefGenome
Efflux transmembrane transporter activitydefinition[GO:0015562]  
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  • UniProtKB
GO biological process 
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependentdefinition[GO:0002485]  
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  • RefGenome
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependentdefinition[GO:0002489]  
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  • RefGenome
Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentdefinition[GO:0002481]  
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  • RefGenome
ATP catabolic processdefinition[GO:0006200]  
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  • InterPro 2 GO
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Compound eye corneal lens developmentdefinition[GO:0048058]  
1
  • Ortholog Curator
Positive regulation of antigen processing and presentation of peptide antigen via MHC class Idefinition[GO:0002591]  
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  • RefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • UniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+340273  
According to Reactome, this protein belongs to the following pathway:
ABC-family proteins mediated transport  REACT_15480  
Note 
Acts as a marker of stem-like cells (CSC) in a number of malignancies (PubMed24934811). Associated with clinical drug resistance, tumor progression and disease recurrence in malignant melanoma and acute leukemias. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. ABCB5-expressing cells selectively survive when exposed to dacarbazine drug, the reference treatment of metastatic melanoma, vemurafenib and other various chemotherapeutic drugs, suggesting that anti-melanoma chemotherapy participates to the chemoresistance acquisition by selecting tumor cell subpopulations expressing ABCB5 (PubMed22784549, PubMed22044138, PubMed22675422, PubMed23770371, PubMed24934811). Present in melanoma-initiating cells that acts as an enhancer of tumor growth by promoting CSC maintenance and tumor growth by controlling IL-1beta (IL1B) secretion to maintain slow-cycling, chemoresistant cells through an IL-1beta (IL1B)/IL8/CXCR1 cytokine signaling circuit (PubMed24934811).  
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  • UniProtKB
Caution 
Was named ABCB1 by some authors.  
1
  • UniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB5
GenomeRNAi: 340273
PRO: PR:Q2M3G0