ABCB5 - ATP-binding cassette sub-family B member 5 - human protein (Function)
 
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ABCB5 »  ATP-binding cassette sub-family B member 5
 
Protein also known as:  P-glycoprotein ABCB5.
Gene name:  ABCB5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.13  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IBARefGenome
Efflux transmembrane transporter activitydefinition[GO:0015562]  
1
  • IDAUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200] silver  
  • IBARefGenome
Metabolic processdefinition[GO:0008152] silver  
  • IBARefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDAUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+340273  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells.  
  • CuratedUniProtKB
Caution 
Was named ABCB1 by some authors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB5
GenomeRNAi: 340273
PRO: PR:Q2M3G0