RSPO1 - R-spondin-1 - human protein (Function)
 
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RSPO1 »  R-spondin-1
 
Protein also known as:  Roof plate-specific spondin-1.
Gene name:  RSPO1
Family name: R-spondin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.  
8
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • IPIUniProtKB
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Male meiosisdefinition[GO:0007140] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of non-canonical Wnt signaling pathwaydefinition[GO:2000052] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDAUniProtKB
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • IDAUniProtKB
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Regulation of male germ cell proliferationdefinition[GO:2000254] silver  
  • IEAOrtholog Compara
Regulation of receptor internalizationdefinition[GO:0002090]  
1
  • IDABHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_200716  
Note 
Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis suggesting possible therapeutic application in gastrointestinal diseases.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RSPO1
GenomeRNAi: 284654
PRO: PR:Q2MKA7