ERCC6L - DNA excision repair protein ERCC-6-like - human protein (Function)
 
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Protein
Gene
References

 
ERCC6L »  DNA excision repair protein ERCC-6-like   [ EC 3.6.4.12 ]
 
Protein also known as:  PLK1-interacting checkpoint helicase.
Gene name:  ERCC6L
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Helicase activitydefinition[GO:0004386]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54821
PRO: PR:Q2NKX8