EIF2S3L - Putative eukaryotic translation initiation factor 2 subunit 3-like protein - human protein (Function)
 
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Protein
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EIF2S3L »  Putative eukaryotic translation initiation factor 2 subunit 3-like protein
 
Protein also known as:  Eukaryotic translation initiation factor 2 subunit gamma A (eIF-2gA).
Gene name:  EIF2S3L
Entry whose protein(s) existence is uncertain. Could be the product of a pseudogene. Evidence for transcription scarce. To the best of our knowledge, peptides that have been sequenced so far and that were identical to the canonical sequence displayed in this entry are common to both EIF2S3 and EIF2S3L and thus do not allow to discriminate both proteins. Protein sequence data have been included in EIF2S3 entry.
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Function

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Overview 
EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Translation initiation factor activitydefinition[GO:0003743]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]