UVSSA - UV-stimulated scaffold protein A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
UVSSA »  UV-stimulated scaffold protein A
 
Gene name:  UVSSA
Family name: UVSSA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 2
GENE REF ISO

Function

 show evidences
Overview 
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
RNA polymerase II core bindingdefinition[GO:0000993]  
3
  • IDAUniProtKB
GO biological process 
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IMPUniProtKB
Response to UVdefinition[GO:0009411]  
3
  • IMPUniProtKB
Transcription-coupled nucleotide-excision repairdefinition[GO:0006283]  
3
  • IMPUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KIAA1530
GenomeRNAi: 57654
PRO: PR:Q2YD98