ANO4 - Anoctamin-4 - human protein (Function)
 
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Protein
Gene
References

 
ANO4 »  Anoctamin-4
 
Protein also known as:  Transmembrane protein 16D.
Gene name:  ANO4
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 27 3
GENE REF ISO

Function

 show evidences
Overview 
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.  
2
  • UniProtKB
GO molecular function 
Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
1
  • UniProtKB
Phospholipid scramblase activitydefinition[GO:0017128] silver  
1
  • Ortholog Compara
GO biological process 
Calcium activated galactosylceramide scramblingdefinition[GO:0061591] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylcholine scramblingdefinition[GO:0061590] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylserine scramblingdefinition[GO:0061589] silver  
1
  • Ortholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • GOC
Chloride transportdefinition[GO:0006821]  
1
  • UniProtKB
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_268444  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 121601
PRO: PR:Q32M45