ANO4 - Anoctamin-4 - human protein (Function)
 
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Protein
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References

 
ANO4 »  Anoctamin-4
 
Protein also known as:  Transmembrane protein 16D.
Gene name:  ANO4
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at transcript level
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1 27 3
GENE REF ISO

Function

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Overview 
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.  
2
  • UniProtKB
GO molecular function 
Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
1
  • UniProtKB
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • GOC
Chloride transportdefinition[GO:0006821]  
1
  • UniProtKB
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_267716  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 121601
PRO: PR:Q32M45