MYLK3 - Myosin light chain kinase 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MYLK3 »  Myosin light chain kinase 3   [ EC 2.7.11.18 ]
 
Protein also known as:  Cardiac-MyBP-C-associated Ca/CaM kinase (Cardiac-MLCK).
Gene name:  MYLK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 2
GENE REF ISO

Function

 show evidences
Overview 
Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • ISSOrtholog Curator
Myosin light chain kinase activitydefinition[GO:0004687]  
  • ISSOrtholog Curator
GO biological process 
Cardiac myofibril assemblydefinition[GO:0055003]  
  • ISSOrtholog Curator
Cellular response to interleukin-1definition[GO:0071347]  
1
  • IMPBHF-UCL
Positive regulation of sarcomere organizationdefinition[GO:0060298]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Regulation of vascular permeability involved in acute inflammatory responsedefinition[GO:0002528]  
1
  • IMPBHF-UCL
Sarcomere organizationdefinition[GO:0045214]  
  • ISSOrtholog Curator
Sarcomerogenesisdefinition[GO:0048769]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.18: ATP + [myosin light-chain] ADP + [myosin light-chain] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+91807  
Focal adhesion  hsa04510+91807  
Gastric acid secretion  hsa04971+91807  
Regulation of actin cytoskeleton  hsa04810+91807  
Vascular smooth muscle contraction  hsa04270+91807  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MYLK3
GenomeRNAi: 91807
PRO: PR:Q32MK0
Chemistry
GuidetoPHARMACOLOGY: 2110