LRRFIP1 - Leucine-rich repeat flightless-interacting protein 1 - human protein (Function)
 
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Protein
Gene
References

 
LRRFIP1 »  Leucine-rich repeat flightless-interacting protein 1  (LRR FLII-interacting protein 1)
 
Protein also known as:  TAR RNA-interacting protein.
Gene name:  LRRFIP1
Family name: LRRFIP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 4
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.  
5
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • NASUniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRRFIP1
GenomeRNAi: 9208
PRO: PR:Q32MZ4