LRRK1 - Leucine-rich repeat serine/threonine-protein kinase 1 - human protein (Function)
 
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LRRK1 »  Leucine-rich repeat serine/threonine-protein kinase 1   [ EC 2.7.11.1 ]
 
Gene name:  LRRK1
Entry whose protein(s) existence is based on evidence at protein level
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1 32 2
GENE REF ISO

Function

 show evidences
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Binding of GTP stimulates kinase activity.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRRK1
GenomeRNAi: 79705
PRO: PR:Q38SD2