LRRK1 - Leucine-rich repeat serine/threonine-protein kinase 1 - human protein (Function)
 
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LRRK1 »  Leucine-rich repeat serine/threonine-protein kinase 1   [ EC 2.7.11.1 ]
 
Gene name:  LRRK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB KW
GO biological process 
Bone resorptiondefinition[GO:0045453] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732] silver  
1
  • Ortholog Compara
Osteoclast developmentdefinition[GO:0036035] silver  
1
  • Ortholog Compara
Positive regulation of intracellular signal transductiondefinition[GO:1902533] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
1
  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
It is regulated in the following manner
Binding of GTP stimulates kinase activity.  
2
  • UniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRRK1
GenomeRNAi: 79705
PRO: PR:Q38SD2