ADPRM - Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase - human protein (Function)
 
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ADPRM »  Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase   [ EC 3.6.1.16EC 3.6.1.53EC 3.6.1.13 ]
 
Protein also known as:  CDP-choline phosphohydrolase.
Gene name:  ADPRM
Family name: ADPRibase-Mn
Entry whose protein(s) existence is based on evidence at protein level
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1 11 2
GENE REF ISO

Function

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Overview 
Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ADP-ribose diphosphatase activitydefinition[GO:0047631]  
  • IEAEC 2 GO
CDP-glycerol diphosphatase activitydefinition[GO:0047734]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Metabolic processdefinition[GO:0008152]  
  • IEAEC 2 GO
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.6.1.53: CDP-choline + H(2)O CMP + phosphocholine.  
  • CuratedUniProtKB
EC 3.6.1.13: ADP-D-ribose + H(2)O AMP + D-ribose 5-phosphate.  
  • CuratedUniProtKB
EC 3.6.1.16: CDP-glycerol + H(2)O CMP + sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycerophospholipid metabolism  hsa00564+56985  
Purine metabolism  hsa00230+56985  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 56985
PRO: PR:Q3LIE5