DAK - Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) - human protein (Function)
 
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DAK »  Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
 
Gene name:  DAK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
FAD-AMP lyase (cyclizing) activitydefinition[GO:0034012]  
1
  • IDAUniProtKB
Glycerone kinase activitydefinition[GO:0004371]  
2
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Triokinase activitydefinition[GO:0050354]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate phosphorylationdefinition[GO:0046835]  
1
  • IDAUniProtKB
Cellular carbohydrate metabolic processdefinition[GO:0044262]  
2
  • IDAUniProtKB
Glycerol metabolic processdefinition[GO:0006071] silver  
  • IEAInterPro 2 GO
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.1.29: ATP + glycerone ADP + glycerone phosphate.  
1
  • CuratedUniProtKB
EC 2.7.1.28: ATP + D-glyceraldehyde ADP + D-glyceraldehyde 3-phosphate.  
1
  • CuratedUniProtKB
EC 4.6.1.15: FAD AMP + riboflavin cyclic-4',5'-phosphate.  
1
  • CuratedUniProtKB
It requires the following cofactors
Magnesium (By similarity).  
  • CuratedUniProtKB
Manganese or cobalt; for FAD-AMP lyase activity (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Each activity is inhibited by the substrate(s) of the other.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+26007  
Metabolic pathways  hsa01100+26007  
RIG-I-like receptor signaling pathway  hsa04622+26007  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Biophysicochemical properties

Kinetic parameters
KM 11 uM for glyceraldehyde
KM 0.5 uM for dihydroxyacetone
Dependence
pH Optimum pH is 6.6.

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Lyase  definition   [KW-0456]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DAK_(gene)
GenomeRNAi: 26007
PRO: PR:Q3LXA3