ALDH1L2 - Mitochondrial 10-formyltetrahydrofolate dehydrogenase - human protein (Function)
 
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Protein
Gene
References

 
ALDH1L2 »  Mitochondrial 10-formyltetrahydrofolate dehydrogenase   [ EC 1.5.1.6 ]  (mtFDH)
 
Protein also known as:  Aldehyde dehydrogenase family 1 member L2.
Gene name:  ALDH1L2
Family names: In the N-terminal section GART
In the C-terminal section Aldehyde dehydrogenase » ALDH1L
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Formyltetrahydrofolate dehydrogenase activitydefinition[GO:0016155]  
  • IEAEC 2 GO
Hydroxymethyl-, formyl- and related transferase activitydefinition[GO:0016742] silver  
  • IEAInterPro 2 GO
Methyltransferase activitydefinition[GO:0008168] silver  
  • IEAInterPro 2 GO
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptordefinition[GO:0016620] silver  
  • IEAInterPro 2 GO
GO biological process 
10-formyltetrahydrofolate catabolic processdefinition[GO:0009258] silver  
  • IEAInterPro 2 GO
Biosynthetic processdefinition[GO:0009058] silver  
  • IEAInterPro 2 GO
One-carbon metabolic processdefinition[GO:0006730]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.5.1.6: 10-formyltetrahydrofolate + NADP(+) + H(2)O tetrahydrofolate + CO(2) + NADPH.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
One carbon pool by folate  hsa00670+160428  
 

Keywords

Biological process 
One-carbon metabolism  definition   [KW-0554]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALDH1L2
GenomeRNAi: 160428
PRO: PR:Q3SY69