RIC1 - RAB6A-GEF complex partner protein 1 - human protein (Function)
 
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Protein
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RIC1 »  RAB6A-GEF complex partner protein 1
 
Protein also known as:  Connexin-43-interacting protein of 150 kDa.
Gene name:  RIC1
Family name: RIC1
Entry whose protein(s) existence is based on evidence at protein level
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1 29 3
GENE REF ISO

Function

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Overview 
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Rab GTPase bindingdefinition[GO:0017137]  
1
  • UniProtKB
Rab guanyl-nucleotide exchange factor activitydefinition[GO:0017112]  
1
  • UniProtKB
GO biological process 
Negative regulation of cellular protein catabolic processdefinition[GO:1903363]  
1
  • UniProtKB
Positive regulation of Rab GTPase activitydefinition[GO:0032851]  
1
  • UniProtKB
Retrograde transport, endosome to Golgidefinition[GO:0042147]  
1
  • UniProtKB
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57589