FAM132B - Erythroferrone - human protein (Function)
 
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Protein
Gene
References

 
FAM132B »  Erythroferrone
 
Protein also known as:  Complement C1q tumor necrosis factor-related protein 15.
Gene name:  FAM132B
Family name: FAM132
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity).  
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  • UniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
1
  • Ortholog Curator
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • Ortholog Curator
Positive regulation of fatty acid transportdefinition[GO:2000193] silver  
1
  • Ortholog Compara
Regulation of fatty acid metabolic processdefinition[GO:0019217] silver  
1
  • Ortholog Compara
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links