ACSF3 - Acyl-CoA synthetase family member 3, mitochondrial - human protein (Function)
 
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ACSF3 »  Acyl-CoA synthetase family member 3, mitochondrial   [ EC 6.2.1.- ]
 
Gene name:  ACSF3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.  
3
  • UniProtKB
GO molecular function 
Acid-thiol ligase activitydefinition[GO:0016878]  
1
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Malonyl-CoA synthetase activitydefinition[GO:0090409]  
2
  • UniProtKB
GO biological process 
Fatty acid biosynthetic processdefinition[GO:0006633]  
1
  • UniProtKB
Fatty acid metabolic processdefinition[GO:0006631]  
1
  • UniProtKB
Malonate catabolic processdefinition[GO:0090410]  
2
  • UniProtKB
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSF3
GenomeRNAi: 197322
PRO: PR:Q4G176