ANO6 - Anoctamin-6 - human protein (Function)
 
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ANO6 »  Anoctamin-6
 
Protein also known as:  Small-conductance calcium-activated nonselective cation channel (SCAN channel).
Gene name:  ANO6
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the calcium-dependent chloride channel (ca-clc) family  1.A.17.1.4  
GO molecular function 
Calcium activated cation channel activitydefinition[GO:0005227]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Contradiction  Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
2
  • IMPUniProtKB
Voltage-gated chloride channel activitydefinition[GO:0005247]  
1
  • IMPUniProtKB
Voltage-gated ion channel activitydefinition[GO:0005244]  
  • ISSOrtholog Curator
GO biological process 
Activation of blood coagulation via clotting cascadedefinition[GO:0002543]  
1
  • IMPUniProtKB
Blood coagulationdefinition[GO:0007596]  
  • ISSOrtholog Curator
Cation transportdefinition[GO:0006812]  
1
  • IDAUniProtKB
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • IMPGOC
Chloride transportdefinition[GO:0006821]  
2
  • IMPUniProtKB
Phosphatidylserine exposure on blood plateletdefinition[GO:0097045]  
1
  • IMPUniProtKB
Phospholipid scramblingdefinition[GO:0017121]  
  • ISSOrtholog Curator
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • IMPUniProtKB
Regulation of anion transportdefinition[GO:0044070]  
1
  • IMPGOC
Enzymatic activity 
It is regulated in the following manner
Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 196527
PRO: PR:Q4KMQ2