ANO6 - Anoctamin-6 - human protein (Function)
 
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ANO6 »  Anoctamin-6
 
Protein also known as:  Small-conductance calcium-activated nonselective cation channel (SCAN channel).
Gene name:  ANO6
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.  
7
  • UniProtKB
According to TCDB this is a transporter from family:
the calcium-dependent chloride channel (ca-clc) family  1.A.17.1.4  
GO molecular function 
Calcium activated cation channel activitydefinition[GO:0005227]  
2
  • UniProtKB
  • Ortholog Curator
Contradiction  Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
2
  • UniProtKB
Phospholipid scramblase activitydefinition[GO:0017128] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Voltage-gated chloride channel activitydefinition[GO:0005247]  
1
  • UniProtKB
Voltage-gated ion channel activitydefinition[GO:0005244]  
1
  • Ortholog Curator
GO biological process 
Activation of blood coagulation via clotting cascadedefinition[GO:0002543]  
1
  • UniProtKB
Blood coagulationdefinition[GO:0007596]  
1
  • Ortholog Curator
Bone mineralization involved in bone maturationdefinition[GO:0035630] silver  
1
  • Ortholog Compara
Calcium activated galactosylceramide scramblingdefinition[GO:0061591] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylcholine scramblingdefinition[GO:0061590] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylserine scramblingdefinition[GO:0061589] silver  
1
  • Ortholog Compara
Cation transmembrane transportdefinition[GO:0098655]  
3
  • GOC
  • Ortholog Curator
  • Ortholog Compara
Cation transportdefinition[GO:0006812]  
1
  • UniProtKB
Chloride transmembrane transportdefinition[GO:1902476]  
2
  • GOC
  • UniProtKB KW
Chloride transportdefinition[GO:0006821]  
2
  • UniProtKB
Dendritic cell chemotaxisdefinition[GO:0002407] silver  
1
  • Ortholog Compara
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Phosphatidylserine exposure on blood plateletdefinition[GO:0097045]  
1
  • UniProtKB
Phospholipid scramblingdefinition[GO:0017121]  
1
  • Ortholog Curator
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • UniProtKB
Regulation of anion transportdefinition[GO:0044070]  
1
  • GOC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Enzymatic activity 
It is regulated in the following manner
Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_267716  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 196527
PRO: PR:Q4KMQ2