SLC22A6 - Solute carrier family 22 member 6 - human protein (Function)
 
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SLC22A6 »  Solute carrier family 22 member 6
 
Protein also known as:  Renal organic anion transporter 1.
Gene name:  SLC22A6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 4
GENE REF ISO

Function

 show evidences
Overview 
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.  
6
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.19.31  
GO molecular function 
Chloride ion bindingdefinition[GO:0031404] silver  
  • IEAOrtholog Compara
Inorganic anion exchanger activitydefinition[GO:0005452]  
1
  • IDAUniProtKB
Organic anion transmembrane transporter activitydefinition[GO:0008514]  
4
  • IMPUniProtKB
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Sodium-independent organic anion transmembrane transporter activitydefinition[GO:0015347]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
GO biological process 
Alpha-ketoglutarate transportdefinition[GO:0015742]  
1
  • IDAUniProtKB
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IEAInterPro 2 GO
Organic anion transportdefinition[GO:0015711]  
3
  • IMPUniProtKB
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Renal tubular secretiondefinition[GO:0097254]  
3
  • IMPUniProtKB
Response to methotrexatedefinition[GO:0031427] silver  
  • IEAOrtholog Compara
Sodium-independent organic anion transportdefinition[GO:0043252]  
1
  • IDAUniProtKB
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Organic anion transport  REACT_22310  
 

Biophysicochemical properties

Kinetic parameters
KM 141 uM for CMPF
KM 20.5 uM for IS
KM 14 uM for IA
KM 5.77 uM for 2,4-D
KM 11 uM for edaravone
KM 30 uM for adefovir
KM 4 uM for PAH (isoform 2)
KM 9.3 uM for PAH (isoform 1)
KM 46 uM for cidofovir
KM 23.5 uM for HA
Vmax 110 pmol/min/mg enzyme for IA uptake
Vmax 801 pmol/min/mg enzyme for CMPF uptake
Vmax 216 pmol/min/mg enzyme for IS uptake
Vmax 430 pmol/min/mg enzyme for HA uptake
Vmax 534 pmol/min/mg enzyme for 2,4-D uptake

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Organic_anion_transporter_1
GenomeRNAi: 9356
PRO: PR:Q4U2R8
Chemistry
GuidetoPHARMACOLOGY: 1025