PAN2 - PAB-dependent poly(A)-specific ribonuclease subunit PAN2 - human protein (Function)
 
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PAN2 »  PAB-dependent poly(A)-specific ribonuclease subunit PAN2   [ EC 3.1.13.4 ]
 
Protein also known as:  Inactive ubiquitin carboxyl-terminal hydrolase 52.
Gene name:  PAN2
Family name: Peptidase C19 » PAN2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 3
GENE REF ISO

Function

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Overview 
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  
2
  • CuratedUniProtKB
GO molecular function 
3'-5'-exoribonuclease activitydefinition[GO:0000175]  
1
  • IDAUniProtKB
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
Poly(A)-specific ribonuclease activitydefinition[GO:0004535]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
RNA phosphodiester bond hydrolysis, exonucleolyticdefinition[GO:0090503]  
1
  • IDAGOC
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.13.4: Exonucleolytic cleavage of poly(A) to 5'-AMP.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Positively regulated by the regulatory subunit PAN3 (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+9924  
According to Reactome, this protein belongs to the following pathway:
Deadenylation of mRNA  REACT_20514  
Caution 
Has no ubiquitin carboxyl terminal hydrolase activity since it lacks a conserved catalytic Cys at position 525.  
  • CuratedUniProtKB
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
Molecular function 
Exonuclease  definition   [KW-0269]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP52
GenomeRNAi: 9924
PRO: PR:Q504Q3