PAN2 - PAB-dependent poly(A)-specific ribonuclease subunit 2 - human protein (Function)
 
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PAN2 »  PAB-dependent poly(A)-specific ribonuclease subunit 2   [ EC 3.1.13.4 ]
 
Protein also known as:  Inactive ubiquitin carboxyl-terminal hydrolase 52.
Gene name:  PAN2
Family name: Peptidase C19 » PAN2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 3
GENE REF ISO

Function

 show evidences
Overview 
Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein.  
2
  • CuratedUniProtKB
GO molecular function 
3'-5'-exoribonuclease activitydefinition[GO:0000175]  
1
  • IDAUniProtKB
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
Poly(A)-specific ribonuclease activitydefinition[GO:0004535]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Ubiquitin thiolesterase activitydefinition[GO:0004221] silver  
  • IEAInterPro 2 GO
GO biological process 
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decaydefinition[GO:0000184]  
  • IEAUniProtKB KW
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
1
  • IDAGOC
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
1
  • IDAGOC
RNA phosphodiester bond hydrolysis, exonucleolyticdefinition[GO:0090503]  
1
  • IDAGOC
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.13.4: Exonucleolytic cleavage of poly(A) to 5'-AMP.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
RNA degradation  hsa03018+9924  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Metabolism of RNA  REACT_21257  
Caution 
Has no ubiquitin carboxyl terminal hydrolase activity since it lacks a conserved catalytic Cys at position 525.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Nonsense-mediated mRNA decay  definition   [KW-0866]
Molecular function 
Exonuclease  definition   [KW-0269]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP52
GenomeRNAi: 9924
PRO: PR:Q504Q3