AGPAT9 - Glycerol-3-phosphate acyltransferase 3 - human protein (Function)
 
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AGPAT9 »  Glycerol-3-phosphate acyltransferase 3   [ EC 2.3.1.15 ]  (GPAT-3)
 
Protein also known as:  1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10 (AGPAT 10).
Gene name:  AGPAT9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid, or PA).  
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  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
  • IEAEC 2 GO
Glycerol-3-phosphate O-acyltransferase activitydefinition[GO:0004366]  
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  • IDAUniProtKB
GO biological process 
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
  • IEAUniPathway
Regulation of TOR signalingdefinition[GO:0032006]  
1
  • IDAUniProtKB
Triglyceride biosynthetic processdefinition[GO:0019432]  
1
  • IDAUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.3.1.15: Acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate.  
3
  • CuratedUniProtKB
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
3
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by N-ethylmaleimide (NEM).  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+84803  
Glycerophospholipid metabolism  hsa00564+84803  
Metabolic pathways  hsa01100+84803  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Caution 
Despite its name, this protein appears to lack measurable glycerol-3-phosphate acyltransferase activity under some conditions (PMID:19318427).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGPAT9
GenomeRNAi: 84803
PRO: PR:Q53EU6